Naturally Occurring Sin Nombre Virus Genetic Reassortants
نویسندگان
چکیده
منابع مشابه
Sin Nombre virus pathogenesis in Peromyscus maniculatus.
Sin Nombre virus (SNV), a member of the Hantavirus genus, causes acute viral pneumonia in humans and is thought to persistently infect mice. The deer mouse, Peromyscus maniculatus, has been identified as the primary reservoir host for SNV. To understand SNV infection of P. maniculatus, we examined wild deer mice for localization of viral antigens and nucleic acid. Morphologic examination consis...
متن کاملTemporal and spatial analysis of Sin Nombre virus quasispecies in naturally infected rodents.
Sin Nombre virus (SNV) is thought to establish a persistent infection in its natural reservoir, the deer mouse (Peromyscus maniculatus), despite a strong host immune response. SNV-specific neutralizing antibodies were routinely detected in deer mice which maintained virus RNA in the blood and lungs. To determine whether viral diversity played a role in SNV persistence and immune escape in deer ...
متن کاملSin Nombre Virus Infection in Deer Mice, Channel Islands, California
To the Editor: Sin Nombre virus (SNV) is a highly virulent strain of hantavirus associated with rodent hosts in North America (1,2). Documenting the prevalence of SNV in wild rodent populations is an important component of determining risk for exposure and ultimately providing sound recommendations for epidemiologic management (3). Prevalence of SNV is highly variable. Deer mice (Peromyscus man...
متن کاملNatural history of Sin Nombre virus in western Colorado.
A mark-recapture longitudinal study of immunoglobulin G (IgG) antibody to Sin Nombre virus (SNV) in rodent populations in western Colorado (1994-results summarized to October 1997) indicates the presence of SNV or a closely related hantavirus at two sites. Most rodents (principally deer mice, Peromyscus maniculatus, and pinyon mice, P. truei) did not persist on the trapping webs much beyond 1 m...
متن کاملSin Nombre Virus Infection in Field Workers, Colorado, USA
We report 2 cases of Sin Nombre virus (SNV) infection in field workers, possibly contracted through rodent bites. Screening for antibodies to SNV in rodents trapped in 2 seasons showed that 9.77% were seropositive. Quantitative real-time PCR showed that 2 of 79 deer mice had detectable titers of SNV RNA.
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ژورنال
عنوان ژورنال: Virology
سال: 1995
ISSN: 0042-6822
DOI: 10.1006/viro.1995.0071